Statins declare to be a lifeline for patients with prostate cancer

Personalised Prostate cancer treatment: Statins declare to be a lifeline for patients with prostate cancer

Prostate cancer treatment

We all know that prostate cancer is a wide spread disease of men, as common as the breast cancer in women and  causes a considerable mortality in our society. It mostly occurs in the old age, but increasing rate of younger patients have also seen in their 40s or earlier to 50s. So be proactive in reducing the risk of this deadly disease and find a proper prostate cancer treatment.

So following facts urge you to get yourself checked and if found then do
prostate cancer treatment as your 1st step:

  • According to forecasts by the American Cancer Society, in 2015, about 220,800 new cases of prostate cancer will be reported
  • Prostate cancer will cause about 27,540 deaths  a year.
  • One of the men between each seven will be diagnosed with prostate cancer during their lifetime.
  • Old men with age over 65 years are at risk of the prostate cancer than younger.
  • About 38 among all men, a person will die from prostate cancer.
  • It is a serious issue to be diagnosed with prostate cancer but the majority of men made will not die if they get proper  prostate cancer treatment.
  • More than 2.9 million men in the US are the same evidence that prostate cancer can be beaten because of advanced diagnosed and treatment methods of the best-known prostate cancer.

 

Statins prove to be a lifeline for men with advanced prostate cancer


 

Research has cleared that statins drugs that lower the cholestrol level have been proved valuable lifeline drugs for the patients with prostate cancer as well as they help us to relief stress.

A new trial have been made to check it, that shows that these drugs markedly increase the the time for a specific disease to stop responding to the given treatment or to bring resistance for the given treatment, for example the prostate cancer treatment .

The results suggest that men can keep prostate cancer at bay for longer period if they are given statins at the same time as undergoing hormone therapy.

Of 926 patients under the study, men taking statins saw their cancer progress after 27.5 months compared with 17.4 months for those not on the statin drugs.

A mechanism that allow the prostate cancer to become resistant to the given treatments is blocked by the statins- scientists believe.

Dr Iain Frame, director of research at the charity Prostate Cancer UK said:

 Men can often manage advanced prostate cancer for many years by taking hormone therapy, however the treatment eventually stops working and the cancer becomes much more difficult to restrain.

“Whilst we continue to explore why men’s cancers stop responding to hormone therapies, this study suggests that taking statins alongside these established treatments could be an effective and affordable way to extend the time that they can keep the cancer in check. We hope that the findings go on to be verified by further trials.

Statins declare to be a lifeline for patients with prostate cancer

Each year almost 41,000 men in the UK are diagnosed with prostate cancer and 11,000 of them die of the prostate cancer.

Advanced prostate cancer that cannot be removed surgically, can be checked by some drugs targeting the way the male hormone testosterone stimulates tumors.

These drugs work b either cutting off the blood supply of male sex hormone- testosterone or prevent it binding to molecular receptors on the wall of cancer cells. But as time pass, around 18 months, the drugs stop to work. So then after that time the tumor may continue to grow and to produce the testosterone itself.

For such patients on the prostate cancer treatment, the outlook then becomes much more bleak with less than two years of the survival time..

The mode of action of Statins is that these drugs bind themselves to a transporter protein made by the gene SLCO2B that helps a variety of drugs and hormones enter cells.

There was strong evidence to suggest that  these Statin drugs prevented a “precursor” chemical called dehydroepiandrosterone sulphate (DHEAS). This precursor is used to make testosterone from gaining access to tumors.

Previous epidemiological studies have shown “significant associations” between use of statins and showed the results with the reduced incidence of prostate cancer and death, told by the researchers.

But, prostate cancer treatment by taking statins had not been shown to lower the risk of being diagnosed with prostate cancer but it decreases the risk factors of dying with this disease for men and to live with style.

Dr Philip Kantoff, from the Dana-Farber Cancer Institute in Boston, concluded:

The ability of a therapy to thwart the development of lethal PC (prostate cancer) is more important than decreasing the overall incidence.
The widespread use of statins and their established safety profile make them attractive potential anticancer therapeutics as adjuvants (add-ons) to cytotoxic (cell-killing) or androgen-ablating (anti-male hormone) therapies.”

More than 10 prospective trials were currently under way to investigate the potential role of statins as prostate cancer treatment, they told.

The trial did not record what kind of statin the patients were taking, but laboratory analysis showed that the ability of statins to block up-take of DHEAS by cancer cells varied with the type of drug and tumor strain.

The tested four statin, pravastatin – sold in the UK as Lipostat – this Statin has shown the greatest inhibitory results on the given two cell lines.

Personalised Prostate cancer treatment Prostate cancer treatment Statins declare to be a lifeline for patients with prostate cancer